Fluoridating remineralizing of enamel

These kits advantageously comprise separate compositions comprising a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide, in order to optimize the stability of these components for storage and/or the activity of these components upon use. and at a p H of 7.0, said soluble calcium salt has a calcium ion solubility of at least about 800 ppm, said soluble orthophosphate salt has a phosphate ion solubility of at least about 4000 ppm, and said soluble peroxide has a peroxide solubility of at least about 4000 ppm. A method for whitening and remineralizing teeth, said method comprising the steps of: (a) combining a first composition comprising a soluble calcium salt with a second composition comprising a soluble peroxide and a soluble orthophosphate salt to yield a mixture, and (b) during or after said step (a), applying said mixture to said teeth. The method of claim 30, wherein, in said step (b), said mixture is applied using a tray. The method of claim 30, wherein said mixture is applied, in said step (b), after said combining step (a). The method of claim 30, wherein said second composition has a p H from about 2 to about 6. The method of claim 30, wherein said second composition is obtained by combining a p H-control composition having an alkaline p H and a stabilized peroxide composition comprising said soluble peroxide and said soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H. The method of claim 34, wherein at least one of said p H control composition and said stabilized peroxide composition comprises a soluble calcium salt. The method of claim 34, wherein said first composition is an aqueous solution and both of said p H-control composition and said stabilized peroxide compositions are in a gel form. The method of claim 30, wherein said first composition and said second composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A method for whitening and remineralizing teeth, said method comprising the steps of: (a) applying a first composition comprising a soluble calcium salt to said teeth, and (b) after said step (a), applying a second composition comprising a soluble peroxide and a soluble orthophosphate salt to said teeth. The method of claim 38, wherein, in said step (b), said second composistion is applied using a tray. The method of claim 38, wherein said second composition has a p H from about 2 to about 6. The method of claim 38, wherein said first composition is an aqueous solution and said second composition is in a gel form. The method of claim 38, wherein said second composition is obtained by combining a p H-control composition having an alkaline p H and a stabilized peroxide composition comprising said soluble peroxide and said soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H. The method of claim 42, wherein at least one of said p H control composition and said stabilized peroxide composition comprises a soluble calcium salt. The method of claim 42, wherein said first composition is an aqueous solution and both of said p H-control composition and said stabilized peroxide compositions are in a gel form. The method of claim 38, wherein said first composition and said second composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing composition comprising solid particles of a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide. The composition of claim 46, wherein said composition is in a powder form. The composition of claim 46, wherein said composition is a stable dispersion and further comprises a non-aqueous dispersion medium. The composition of claim 48, further comprising a fluoride ion source. 5,698,182 describes a composition for inhibiting dental calculus and whitening teeth comprising an anticalculus phosphate salt and calcium peroxide. Accordingly, in one embodiment, the present invention is a tooth whitening and remineralizing kit comprising a calcium-containing composition and a stabilized peroxide composition.The active ingredients may also be separated in a solid composition (e.g., a powder) or in a stable dispersion comprising a non-aqueous dispersion medium. A tooth whitening and remineralization kit comprising: (a) a calcium-containing composition comprising a soluble calcium salt, and (b) a stabilized peroxide composition comprising a soluble peroxide and a soluble orthophosphate salt. The kit of claim 1, wherein said calcium-containing composition further comprises an agent that catalyzes the break down of peroxide, wherein said agent is a catalytic ion. The kit of claim 1, wherein said calcium-containing composition has an alkaline p H. The kit of claim 3, wherein said calcium-containing composition has a p H from about 8 to about 12. The kit of claim 1, wherein said stabilized peroxide composition has an acidic p H. The kit of claim 5, wherein said stabilized peroxide composition has a p H from about 2 to about 6. The kit of claim 5, further comprising: (c) a p H-control composition having an alkaline p H, wherein said calcium-containing composition, said stabilized peroxide composition, and said p H-control composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing kit comprising: (a) a calcium-containing composition comprising a soluble calcium salt, (b) a stabilized peroxide composition comprising a soluble peroxide and having an acidic p H, and (c) a orthophosphate-containing composition comprising a soluble orthophosphate salt, wherein said calcium-containing composition, said stabilized peroxide composition, and said orthophosphate-containing composition, when combined in an aqueous environment, yield a mixture having a p H from about 5 to about 9. A tooth whitening and remineralizing kit comprising: (a) a p H-control composition having an alkaline p H; (b) a stabilized peroxide composition comprising a soluble peroxide and a soluble orthophosphate salt, wherein said stabilized peroxide composition has an acidic p H, wherein at least one of said p H-control composition and said stabilized phosphate composition comprises a soluble calcium salt. A tooth whitening and remineralizing kit comprising: (a) a p H-control composition having an alkaline p H, and (b) a stabilized peroxide composition comprising a soluble peroxide and a calcium orthophosphate solution, wherein said stabilized peroxide composition has an acidic p H. The kit of claim 10, wherein said p H-control composition is in a gel form that is p H-adjusted with a hydroxide compound or a carbonate compound. The kit of claim 10, wherein said stabilized peroxide composition is in a gel form having said calcium orthophosphate dissolved therein. The kit of claim 1, wherein said soluble calcium salt is selected from the group consisting of: (a) calcium sulfate; (b) calcium chloride; (c) calcium nitrate; (d) calcium acetate; (e) calcium lactate; and (f) combinations thereof. The kit of claim 1, wherein said soluble orthophosphate salt is selected from the group consisting of: (a) a peroxyorthophosphate; (b) monosodium phosphate; (c) disodium phosphate; (d) trisodium phosphate; (e) monopotassium phosphate; (f) dipotassium phosphate; (g) tripotassium phosphate; (h) monoammonium phosphate; (i) diammonium phosphate; (j) triammonium phosphate; (k) monocalcium phosphate monohydrate (MCMP); (l) monocalcium phosphate anhydrate (MCPA); and (m) combinations thereof. The kit of claim 14, wherein said peroxyphosphate is selected from the group consisting of: (a) a peroxymonophosphate; (b) a diperoxymonophosphate; and (c) combinations thereof. The kit of claim 15, wherein said peroxymonophosphate is selected from the group consisting of: (a) monopotassium peroxymonophosphate; (b) dipotassium peroxymonophosphate; (c) tripotassium peroxymonophosphate; (d) monosodium peroxymonophosphate; (e) disodium peroxymonophosphate; (f) trisodium peroxymonophosphate; (g) monoammonium peroxymonophosphate; (h) diammonium peroxymonophosphate; (i) triammonium peroxymonophosphate; and (j) combinations thereof. The kit of claim 15, wherein said diperoxymonophosphate is selected from the group consisting of: (a) monopotassium diperoxymonophosphate; (b) dipotassium diperoxymonophosphate; (c) tripotassium diperoxymonophosphate; (d) monosodium diperoxymonophosphate; (e) disodium diperoxymonophosphate; (f) trisodium diperoxymonophosphate; (g) monoammonium diperoxymonophosphate; (h) diammonium diperoxymonophosphate; (i) triammonium diperoxymonophosphate; and (j) combinations thereof. The kit of claim 1, wherein said soluble peroxide is selected from the group consisting of: (a) hydrogen peroxide; (b) urea peroxide (carbamide); (c) a peroxyphosphate; (d) orthophosphate peroxyhydrate; (e) pyrophosphate peroxyhydrate; (f) triphosphate peroxyhydrate; (g) metaphosphate peroxyhydrate; (h) peroxyborate; (i) peroxycarbonate; (j) peroxysilicate; and (k) combinations thereof. The kit of claim 18, wherein said peroxyphosphate is selected from the group consisting of: (a) a peroxymonophosphate; (b) a peroxydiphosphate; (c) a diperoxymonophosphate; and (d) combinations thereof. The kit of claim 19, wherein said peroxymonophosphate is selected from the group consisting of: (a) monopotassium peroxymonophosphate; (b) dipotassium peroxymonophosphate; (c) tripotassium peroxymonophosphate; (d) monosodium peroxymonophosphate; (e) disodium peroxymonophosphate; (f) trisodium peroxymonophosphate; (g) monoammonium peroxymonophosphate; (h) diammonium peroxymonophosphate; (i) triammonium peroxymonophosphate; and (j) combinations thereof. The kit of claim 19, wherein said peroxydiphosphate is selected from the group consisting of: (a) monopotassium peroxydiphosphate; (b) dipotassium peroxydiphosphate; (c) tripotassium peroxydiphosphate; (d) tetrapotassium peroxydiphosphate; (e) monosodium peroxydiphosphate; (f) disodium peroxydiphosphate; (g) trisodium peroxydiphosphate; (h) tetrasodium peroxydiphosphate; (i) monoammonium peroxydiphosphate; (j) diammonium peroxydiphosphate; (k) triammonium peroxydiphosphate; (l) tetraammonium peroxydiphosphate; and (m) combinations thereof. The kit of claim 19, wherein said diperoxymonophosphate is selected from the group consisting of: (a) monopotassium diperoxymonophosphate; (b) dipotassium diperoxymonophosphate; (c) tripotassium diperoxymonophosphate; (d) monosodium diperoxymonophosphate; (e) disodium diperoxymonophosphate; (f) trisodium diperoxymonophosphate; (g) monoammonium diperoxymonophosphate; (h) diammonium diperoxymonophosphate; (i) triammonium diperoxymonophosphate; and (j) combinations thereof. The kit of claim 18, wherein said orthophosphate peroxyhydrate is selected from the group consisting of: (a) sodium orthophosphate peroxyhydrate; (b) potassium orthophosphate peroxyhydrate; (c) ammonium orthophosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said pyrophosphate peroxyhydrate is selected from the group consisting of: (a) sodium pyrophosphate peroxyhydrate; (b) potassium pyrophosphate peroxyhydrate; (c) ammonium pyrophosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said triphosphate peroxyhydrate is selected from the group consisting of: (a) sodium triphosphate peroxyhydrate; (b) potassium triphosphate peroxyhydrate; (c) ammonium triphosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 18, wherein said metaphosphate peroxyhydrate is selected from the group consisting of: (a) sodium metaphosphate peroxyhydrate; (b) potassium metaphosphate peroxyhydrate; (c) ammonium metaphosphate peroxyhydrate; and (d) combinations thereof. The kit of claim 1, wherein said stabilized peroxide composition further comprises a fluoride ion source. The kit of claim 27, wherein said fluoride ion source is selected from the group consisting of: (a) sodium fluoride; (b) potassium fluoride; (c) sodium monofluorophosphate; (d) sodium hexafluorosilicate; and (e) combinations thereof. The present invention relates to compositions and methods for whitening, mineralizing, and/or fluoridating teeth. Also included in the composition is calcined alumina. The calcium-containing composition comprises a soluble calcium salt.By continuing to use this site, you consent to the use of cookies.We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. As an alternative means of separating a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide prior to use, these components may be provided in a tooth whitening and remineralizing composition comprising solid particles, such as a powder composition. In particular, without being bound by theory, it has now been determined that (i) peroxide in solution may be stabilized in the presence of orthophosphate ion and/or in a composition at acidic p H, (ii) conversely, in order for peroxide to become activated for tooth whitening upon use, it may be destabilized by removing the soluble orthophosphate ion and/or increasing p H, and (iii) calcium orthophosphate solutions at high concentrations suitable for tooth remineralization may be stabilized at acidic p H and precipitated onto the tooth surface by increasing p H. There is also a need in the art for methods that achieve simultaneous whitening and remineralization of teeth in this manner.

Kits of the present invention employ a soluble calcium salt, a soluble orthophosphate salt, and a soluble peroxide.

The present invention is directed to kits and methods that utilize a stabilized peroxide composition to combine whitening/stain removal of teeth with remineralization.

6,303,104 describes an oral product for remineralizing and whitening teeth comprising a first component composed of a calcium compound and optionally a non-calcium divalent metal salt or an anhydrous calcium phosphate or dicalcium phosphate abrasive and a second component composed of an orthophosphate compound. However, complete stabilization of peroxide is also not a desirable objective, since the breakdown of peroxide is necessary upon use, in order to provide the free perhydroxyl anion/radical that is effective for whitening.

The compositions advantageously whiten teeth while simultaneously remineralizing them to prevent and/or repair weaknesses including dental caries, exposed dentin tubules, and voids resulting from stain removal. The stabilized peroxide composition comprises a soluble peroxide and a soluble orthophosphate salt.

A tooth is comprised of an outer hard enamel protective layer surrounding an inner dentin layer. 5,851,514 describes a whitening composition containing both a peroxide compound and an abrasive compound. In a preferred embodiment, the calcium-containing composition has an alkaline p H and the stabilized peroxide composition has an acidic p H.

Search for fluoridating remineralizing of enamel:

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On the root end of the tooth, these tubules are also sealed by a bony material called cementum. These compositions comprise an acyl group (or functionally similar group) source or precursor and a peroxide source or precursor [e.g., urea peroxide (carbamide), sodium percarbonate, sodium perborate, calcium peroxide, magnesium peroxide, or sodium peroxide], which react in an aqueous environment to generate a peroxyacid (e.g., peroxyacetic acid). In a third embodiment, the present invention is a tooth whitening and remineralizing kit comprising a p H-control composition and a stabilized peroxide composition. The stabilized peroxide composition comprises a soluble peroxide and a soluble orthophosphate salt, wherein the stabilized peroxide composition has an acidic p H.

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